Scientists create embryos

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New spectre of cloned babies: Scientists create embryos in lab that ‘could grow to full term’
– Breakthrough could have major implications for stem cell treatments
– First time cloned embryos have developed enough to provide stem cells
– Raises possibility of babies being cloned in the lab by rogue scientists
The prospect of cloned babies has moved a step closer after scientists extracted stem cells from human embryos created in a laboratory.
The breakthrough could lead to customised cells to help treat and even cure a range of diseases, from Alzheimer’s to multiple sclerosis.
However, it also raises the spectre of babies being cloned in laboratories. This could allow couples who lose a child to pay for the creation of a ‘duplicate’.
While human embryos have been cloned before, none have had healthy stem cells extracted from them. The latest advance means scientists are now even closer to being able to clone children.
The US team behind the work stress that they want to find treatments for incurable diseases – but critics fear there is little to stop a rogue scientist from copying their work to try to clone humans.
Dr David King, founder of the campaign group Human Genetics Alert, called for an international ban on human cloning and said it was ‘irresponsible in the extreme’ to have published details of the stem-cell technique.
The world first was achieved at Oregon Health and Science University, with a technique similar to the one used to clone Dolly the sheep.
First, Dr Shoukhrat Mitalipov took eggs donated by healthy young women and removed their DNA.
He then placed skin cells inside the hollowed-out eggs and used a zap of electricity to make them start developing into embryos.
When the embryos were five or six days old, and around the size of a pinhead, Dr Mitalipov successfully harvested them for stem cells.
These cells, known as ‘master cells’, are capable of turning into every type of cell in the body and are widely seen as a potential repair kit for diseased, damaged and worn-out body parts.
Dr Mitalipov has spent many years refining the technique, which involves feeding the eggs caffeine at a key point in the process.
He said: ‘Our finding offers new ways of generating stem cells for patients with dysfunctional or damaged tissues and organs.
‘Such stem cells can regenerate and replace those damaged cells and tissues and alleviate diseases that affect millions of people.
‘While there is much work to be done in developing safe and effective stem-cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine.’
Using a sliver of the patient’s skin at the start of the process would ensure that stem cells would be a perfect match for their body.
This would raise the odds of the treatment being successful, and remove the need for powerful drugs to suppress the patient’s immune system.
Tailor-made cells could also be used to learn more about a person’s illness, and test drugs to find those that work best.
Chris Mason, a professor of regenerative medicine at University College London, said Dr Mitalipov’s work, detailed in the journal Cell, looked like ‘the real deal’.
Dr Paul De Sousa, of Edinburgh University, said that improving our understanding of women’s eggs could lead to new treatments for infertility. However, other scientists warned that the new research brings us closer to babies being cloned to order.

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